MovDisordV3, Main, Exploration, bibRecord, 002451

Anatomy, physiology, and pathophysiology of the pedunculopontine nucleus

Identifieur interne : 002451 ( Main/Exploration ); précédent : 002450; suivant : 002452

Anatomy, physiology, and pathophysiology of the pedunculopontine nucleus

Auteurs : Ned Jenkinson [Royaume-Uni] ; Dipanker Nandi [Royaume-Uni] ; Kalai Muthusamy [Royaume-Uni] ; Nicola J. Ray [Royaume-Uni] ; Ralph Gregory [Royaume-Uni] ; John F. Stein [Royaume-Uni] ; Tipu Z. Aziz [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2009-02-15.

RBID : ISTEX:F8A804FC7A5031E670C1DF07EEB78B934B925243

Descripteurs français

Pascal (Inist)
- Anatomie, Maladie de Parkinson, Pathologie du système nerveux, Physiologie, Physiopathologie.
Wicri :
- topic : Anatomie.

English descriptors

KwdEn :
- Anatomy, Animals, Electric Stimulation (methods), Humans, Nervous system diseases, PPN, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Pathophysiology, Pedunculopontine Tegmental Nucleus (anatomy & histology), Pedunculopontine Tegmental Nucleus (physiology), Pedunculopontine Tegmental Nucleus (physiopathology), Physiology, anatomy, pedunculopontine, physiology.
MESH :
- anatomy & histology : Pedunculopontine Tegmental Nucleus.
- diagnosis : Parkinson Disease.
- methods : Electric Stimulation.
- physiology : Pedunculopontine Tegmental Nucleus.
- physiopathology : Parkinson Disease, Pedunculopontine Tegmental Nucleus.
- therapy : Parkinson Disease.
- Animals, Humans.

Abstract

The pedunculopontine nucleus is composed of cholinergic and non‐cholinergic neurones and is located in the caudal pontomesencephalic tegmentum. Evidence suggests that the nucleus plays a role in the production and control of movement. The nucleus has dense interconnections with the basal ganglia, as well as with other areas of the brain associated with motor control. Electrical stimulation of the pedunculopontine nucleus in the decerebrate cat or rat produces organized locomotor movements. Physiological studies show that the pedunculopontine nucleus modulates its activity in response to locomotion, as well as voluntary arm and eye movements. Degeneration of the pedunculopontine nucleus is seen in post‐mortem brains in humans with Parkinson's disease and Parkinsonian syndromes. In animal models of Parkinson's disease, metabolic changes are seen in the pedunculopontine nucleus, and chemical inhibition or mechanical disruption of the nucleus can produce an akinetic state in animals and man. In this paper we review the literature in support of the suggestion that some of the symptoms of Parkinson's disease are caused by dysfunction of the pedunculopontine nucleus. In accordance with this view, direct stimulation of the nucleus can ameliorate some symptoms of the disease, as demonstrated in both experimental animals and man. © 2008 Movement Disorder Society

Url:

https://api.istex.fr/document/F8A804FC7A5031E670C1DF07EEB78B934B925243/fulltext/pdf

DOI: 10.1002/mds.22189

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">The pedunculopontine nucleus is composed of cholinergic and non‐cholinergic neurones and is located in the caudal pontomesencephalic tegmentum. Evidence suggests that the nucleus plays a role in the production and control of movement. The nucleus has dense interconnections with the basal ganglia, as well as with other areas of the brain associated with motor control. Electrical stimulation of the pedunculopontine nucleus in the decerebrate cat or rat produces organized locomotor movements. Physiological studies show that the pedunculopontine nucleus modulates its activity in response to locomotion, as well as voluntary arm and eye movements. Degeneration of the pedunculopontine nucleus is seen in post‐mortem brains in humans with Parkinson's disease and Parkinsonian syndromes. In animal models of Parkinson's disease, metabolic changes are seen in the pedunculopontine nucleus, and chemical inhibition or mechanical disruption of the nucleus can produce an akinetic state in animals and man. In this paper we review the literature in support of the suggestion that some of the symptoms of Parkinson's disease are caused by dysfunction of the pedunculopontine nucleus. In accordance with this view, direct stimulation of the nucleus can ameliorate some symptoms of the disease, as demonstrated in both experimental animals and man. © 2008 Movement Disorder Society</div>
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Movement Disorders (revue)

Anatomy, physiology, and pathophysiology of the pedunculopontine nucleus

Anatomy, physiology, and pathophysiology of the pedunculopontine nucleus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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